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Srinivasa Sastry, D.
- Simultaneous Estimation of Metformin Glimeperide and Voglibose by RP-UPLC
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Aditya Pharmacy College, Surampalem, Andhra Pradesh, IN
2 Nitte University, NGSMIPS, Department of Pharmaceutical Chemistry, Mangalore, Karnataka, IN
1 Department of Pharmaceutical Chemistry, Aditya Pharmacy College, Surampalem, Andhra Pradesh, IN
2 Nitte University, NGSMIPS, Department of Pharmaceutical Chemistry, Mangalore, Karnataka, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 1 (2017), Pagination: 23-30Abstract
A simple, sensitive and precise RP-UPLC method for estimation of Metformin, Glimeperide and Voglibose has been developed and validated for determination of compounds in commercial tablet dosage form. The compounds were well separated isocratically on a Inertsil ODS column using a mobile phase consisting of buffer (pH 3), and Methanol in the ratio of 70:30 v/v 0.4 ml/min flow rate with PDA detector. Retention time for Metformin, Glimeperide and Voglibose was found to be 0.903, 2.619, 3.818 min respectively. The method was validated in accordance with ICH guidelines. The study showed that the reverse phased liquid chromatography was sensitive and selective for detecting Metformin, Glimeperide and Voglibose using the single mobile phase.Keywords
Metformin, Glimeperide, Voglibose Ultra Performance Liquid Chromatography, Validation, Degaradation.- Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent
Abstract Views :168 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, IN
2 Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka – 575 018, IN
1 Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, IN
2 Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka – 575 018, IN